Azamacrocycles as a novel class of antitumoral and antimicrobial agents
Cancer remains one of the major contributors to premature deaths worldwide having an impact not only on individual health, but also on the national health and social systems. In addition, the extensive emergence of antimicrobial-resistant bacteria strains is directly associated with an increased risk of morbidity and mortality. This research project aims to the development of a novel class of antitumoral and antimicrobial agents based on azamacrocycles that comprises synthesis and mechanistic studies of action in both prokaryotic and eukaryotic cells. The development of novel azamacrocycles that could combine both antitumoral and antimicrobial properties is a high goal that may be anticipated from the appropriate design of target compounds.
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Eco-friendly coatings based on azamacrocycles for biofouling prevention
The most effective bio-decontamination strategies comprise the controlled release of toxic and cumulative bioactive agents into water, which imply limited life-cycle, significant ecotoxicity, and promotion of human pathogens resistance. This work aims to develop a new antimicrobial alternative for water bio-decontamination by tailoring new azamacrocycle derivatives to generate non-toxic protective coatings. Antifouling efficacy and coating properties are assessed following international standards. |